Saez-Rodriguez Group

Systems biomedicine

Federica Eduati

I received my Bachelor's degree in Biomedical Engineering in 2006 and my Master's degree in Bioiengineering in 2008 both from the University of Padova. During my PhD studies (2009-2012) I worked in the field of Systems Biology using different computational modeling approaches in order to gain new insights into biological systems, focusing on the analysis of how models of different complexity appropriately describe the available data to achieve a given purpose. In 2009 I participated to the DREAM4 “Predictive signaling network modeling” challenge classifying as best performing team. In 2011-2012 I was a visiting predoctoral fellow for 8 months in the Systems Biomedicine group at EBI. I joined Saez-Rodriguez group in February 2013 as EIPOD postdoctoral fellow in collaboration with Merten group in EMBL-Heidelberg, to work on the development of a droplet-based microfluidic platform for functional combinatorial drug screening of patient samples. In 2013 I was co-organizer of the NIEHS-NCATS-UNC DREAM Toxicogenetics Challenge.

Tel:+ 44 (0) 1223 494 682 / Fax:+ 44 (0) 1223 494 468

Research interests

As a postdoc in Julio Saez-Rodriguez group, my main research interest is currently the investigation of why patients differentially respond to cancer therapy and how we can suggest the best therapy for each patient. In particular, I am interested in approaching the complex problem of precision medicine investigating signaling pathways, their deregulation in cancer and the specific effect of targeted therapy, using dynamic modeling approaches.

Since precision medicine would largely benefit from the possibility to perform phenotypic drug screening directly on live patient tumor cells, I have also been working (with Merten group, EMBL Heidelberg) on the development of a microfluidics platform, which allows to screen cells obtained from patient biopsies in a fast (less than 48 hours from surgery) and cost effective way (~ US$ 150 per patient).

I am particularly enjoying the interdisciplinarity that characterize my postdoc experience, which gives me the possibility to follow my main passion of analyzing data using mathematical models, but working always in collaboration with clinicians and biologists and spending also time in the wet lab, challenging myself by being personally involved in the design and performance of experiments.

Professional Career

2016-present Visiting Scientist at JRC-COMBINE, RWTH-Aachen University Hospital, Germany
2013-present Postdoctoral EIPOD fellow - Marie Curie Fellow at European Bioinformatics Institute (EMBL-EBI, UK), with joint appointment at the European Molecular Biology Laboratory (Genome Biology Unit, Germany)
2011-2012 Visiting Predoctoral Fellow at European Bioinformatics Institute (EMBL-EBI, UK)
2009 Research Assistant at Department of Information Engineering, University of Padova, Italy

Education

2010-2013 PhD in Information Engineering – Bioengineering, University of Padova, Italy
2007 Exchange Erasmus student at Universitat Pompeu Fabra (UPF), Spain
2006-2008 M.Sc. in Bioengineering, University of Padova, Italy (grade: 110/110 summa cum laude)
2003-2006 B.Sc. in Biomedical Engineering, University of Padova, Italy (grade: 110/110 summa cum laude)