Saez-Rodriguez Group

Systems biomedicine

Christian Holland

In 2011 I started my studies in molecular Biotechnology at Bielefeld University and received my Bachelor’s degree in 2014. During my Bachelor’s Thesis i made first experiences in modeling and simulation of single pathways. Since I wanted to keep the focus on Systems Biology/Computational Biology rather than on molecular Biotechnology I decided to apply to the master’s program “Genome based Systems Biology” in Bielefeld. From July 2016 - February 2017 I wrote my Master’s Thesis at Insilico Biotechnology AG in Stuttgart. During this time I developed a method to couple a dynamic metabolic network with a regulatory model based on Boolean algebra to improve the predictive power of the integrated model. In May 2017 I joined the group of Prof. Dr. Julio Saez-Rodriguez as a PhD student. I work on the Liver Systems Medicine (LiSyM) project with focus on the analysis of gene expression data to gain a better understanding of liver diseases.

Research Interests

My main research interest is to develop and implement computational methods in a biomedical context. Mostly I utilize my native programming language Python, however, I have also experience in R and MATLAB. Moreover I am interested in systematic analysis and visualization of heterogeneous datasets in order to identify structures and patterns which help to understand (liver) diseases.

Professional career

2016-2017 Master’s Thesis at Insilico Biotechnology AG, Stuttgart, Germany
2016 Internship at Alacris Theranostics GmbH, Berlin, Germany

Education

2017-present PhD student in mechanistic modeling at JRC Combine, RWTH Aachen, Germany
2014-2017 Master of Science in Genome based Systems Biology, Bielefeld University, Germany
2011-2014 Bachelor of Science in molecular Biotechnology, Bielefeld University, Germany