Saez-Rodriguez Group

Systems Biomedicine

Angeliki Kalamara

After obtaining my Diploma in Computer Engineering from the Polytechnic School at University of Patras I continued my Master studies with specialization in Bioinformatics at National and Kapodistrian University. During the last year of my master’s degree I spent half of my research term at INRIA Sophia-­Antipolis, as an intern in the Algorithms Biology Structure (ABS) team where I dealt with Cryo­–Electron Microscopy maps segmentation to detect the individual protein complex’s subunits by heavily relying on computational geometry methods. Afterwards, I joined Dr. Julio Saez-Rodriguez’s group at the European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI) as an intern where my main project was the association of cancer patients to drug response. Currently, I conduct my PhD research at Julio Saez-Rodriguez’s group at the Joint Research Center for Computational Biomedicine where I continue my work on the in vivo drug prediction in the context of cancer.

Research Interests

Cancer is a highly heterogeneous disease with complex underlying biology. For these reasons, effective cancer treatment is still a challenge. Nowadays, it is clear that a cancer therapy that fits all the cases cannot be found, and as a result the design of therapies tailored to the patient’s molecular characteristics is needed.

My research interests cover the area of cancer pharacogenomics which aims to describe how an individual’s genetic make-up responds to a cancer agent. Pharmacogenomics holds the promise to find biomarkers to improve patient treatment and stratification in cancer. In my research I exploit machine learning approaches to predict the relationship between a genotype and a drug with the ultimate goal to translate these findings to the clinic.

Professional Career

2014-2015 Internship at European Bioinformatics Institute (EMBL-EBI), Systems Biomedicine Group
2013 Internship at INRIA Sophia-Antipolis, Structural Bioinformatics

Education

2015-present PhD student in mechanistic modeling at JRC Combine, RWTH Aachen, Germany
2011-2014 MSc in Bioinformatics, National and Kapodistrian University of Athens
2005-2011 5-year Diploma in Computer Engineering and Informatics, University of Patras

Featured Publications