Saez-Rodriguez Group

Systems Biomedicine

Javier Perales-Patón

During my education, I have acquired knowledge in Molecular Biology, Genetics and Computational Biology. I obtained my Bachelor of Science in Biology from Universidad Complutense de Madrid (UCM) in 2012, with a double specialization in Genetics and Biotechnology. In 2013, I obtained the Master in Science in Bioinformatics and Computational Biology from the Spanish National School of Public Health – Health Institute Carlos III (Madrid, Spain). I carried out my master’s thesis at Dr. Pilar Santisteban’s group at the Biomedical research Institute – “Alberto Sols” (UAM-CSIC, Madrid, Spain), where we deciphered the transcriptional dysregulation of a protein transporter responsible of the treatment outcome of radioactive iodine in thyroid cancer. In 2014, I joined the Bioinformatics Unit at the Spanish National Cancer Research Centre (CNIO, Madrid, Spain), led by Dr. Fátima Al-Shahrour. I held a predoctoral fellowship Severo Ochoa (MINECO, Spain) to carry out a Ph.D. My research activity was focused on the identification of novel therapeutic opportunities for pancreatic ductal adenocarcinoma from different perspectives of the disease (tumour subtypes, molecular dependencies, disease inception, etc). I have been also involved in postgraduate courses in Bioinformatics at different institutions as an instructor, with a topic focus on personalized medicine. In 2019, I joined the Saez-Rodriguez group to investigate the molecular mechanisms driving human diseases such as tissue fibrosis and cancer using single-cell omics and functional genomics.

Research Interests

My main interest is to gain a better understanding of human diseases from the molecular perspective. I am interested in learning and developing integrative methods for the large multi-omics data generated by public consortiums and our collaborators. I am very interested in incorporating the prior knowledge published already to improve our models. Particularly, I aim to untangle the complex cellular circuit of dysregulation through the aberrant signals that originate and progress into the disease, and to find molecular weak spots to disrupt or revert it.

Professional Career

2019–Present: Research associate at Saez-Rodriguez’s group, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany.
2014–2018: Computational Biologist at Al-Shahrour’s group - Bioinformatics Unit, Spanish National Cancer Research Centre, Madrid, Spain.
2013–2013: Bioinformatician at Santisteban’s group, Instituto de Investigaciones Biomédicas “Alberto Sols” (IIBm), Madrid, Spain.

Education

2015–2019: Ph.D. in Molecular Biosciences, Autonomous University of Madrid, Madrid, Spain.
2012–2013: M.Sc. in Bioinformatics and Computational Biology, with cum laude, Spanish National School of Public Health - Healthy Institute Carlos III, Madrid, Spain.
2006–2012: B.Sc. in Biology, Complutense University of Madrid, Madrid, Spain.