Saez-Rodriguez Group

Systems Biomedicine

Ana Victoria Ponce-Bobadilla

I have always been passionate about mathematics, it was only after a summer research project in my last year of bachelor studies that I became fascinated by mathematical modelling of biological systems and the rest (as is commonly said) is history. I pursued an Erasmus Mundus Master in Complex Systems Science where I learned a plethora of modelling frameworks to investigate biological phenomena such as cancer dynamics, cell signalling and population dynamics. I had the opportunity to do my master thesis at the Wolfson Centre for Mathematical Biology at Oxford University, where I developed a stochastic model to further understand tumour response to radiotherapy, under the supervisor of Philip Maini and Helen Byrne. Afterwards I decided to pursue a PhD in Applied Mathematics at Heidelberg University under the supervision of Thomas Carraro (Heidelberg), Tomás Alarcón (Centre de Recerca Matematica, Barcelona), and Philip Maini and Helen Byrne (Oxford). During my PhD, I developed mathematical and computational frameworks for understanding scratch assays dynamics. I joined the Saez-Rodriguez group to develop multiscale models of kidney fibrosis.

Research Interests

My research focuses on formulating mathematical and computational models for understanding diseases and treatment response. I have focused primarily on cancer dynamics, while currently I am working on kidney fibrosis. I am particularly interested in:
– Developing multi-scale models that can integrate cross-scale mechanisms and clinical outcomes of the disease.
– Linking models and experimental data through parameter estimation and model selection.
– Combining mathematical frameworks with computational, statistical and machine learning methods to formulate predictive clinically relevant models.

Professional Career

2019-present: Postdoctoral Researcher. Institute for Computational Biomedicine, Heidelberg University, Faculty of Medicine & Heidelberg University Hospital, Germany.
2015-2019: Research Assistant. Institute for Applied Mathematics. Heidelberg University, Germany.
2015-2019: Master Research Student. Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, United Kingdom.
2013: Undergraduate Summer Researcher. Institute for Pure and Applied Mathematics, UCLA, USA.

Education

2015-2019: PhD in Applied Mathematics. Heidelberg University, Germany
2013-2015: Master of Science in Complex Systems Science. First year: University of Warwick, United Kingdom, second year: École Polytechnique, France.
2008-2013: B. Sc. in Mathematics. National Autonomous University of Mexico, Mexico.