Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer.
Tang J NPJ Syst Biol Appl, 2019
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen.
Menden MP Nat Commun, 2019
Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening.
Picco G Nat Commun, 2019
Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling.
Lun XK Mol Cell, 2019
Author Correction: Linking drug target and pathway activation for effective therapy using multi-task learning.
Yang M Sci Rep, 2019
MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAFV600E amplification whereas KRASG13D amplification promotes EMT-chemoresistance.
Sale MJ Nat Commun, 2019
MAPK pathway and B cells overactivation in multiple sclerosis revealed by phosphoproteomics and genomic analysis.
Kotelnikova E Proc Natl Acad Sci U S A, 2019
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Behan FM Nature, 2019
Elastin imaging enables noninvasive staging and treatment monitoring of kidney fibrosis.
Sun Q Sci Transl Med, 2019
Big science and big data in nephrology.
Saez-Rodriguez J Kidney Int, 2019
Multi-omic measurements of heterogeneity in HeLa cells across laboratories.
Liu Y Nat Biotechnol, 2019
The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury.
Späth MR Kidney Int, 2018
Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue.
Pellegrinelli V Nat Commun, 2018
Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury.
Souza T Front Genet, 2018
Computational discovery of dynamic cell line specific Boolean networks from multiplex time-course data.
Razzaq M PLoS Comput Biol, 2018
The germline genetic component of drug sensitivity in cancer cell lines.
Menden MP Nat Commun, 2018
Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting.
Iorio F BMC Genomics, 2018
How to find the right drug for each patient? Advances and challenges in pharmacogenomics
Kalamara et al. Current Opinions in Systems Biology, 2018
A microfluidics platform for combinatorial drug screening on cancer biopsies.
Eduati F Nat Commun, 2018
Linking drug target and pathway activation for effective therapy using multi-task learning.
Yang M Sci Rep, 2018
Alternative models for sharing confidential biomedical data.
Guinney J Nat Biotechnol, 2018
Pathway-based dissection of the genomic heterogeneity of cancer hallmarks’ acquisition with SLAPenrich.
Iorio F Sci Rep, 2018
GDSCTools for mining pharmacogenomic interactions in cancer.
Cokelaer T Bioinformatics, 2018
Whither systems medicine?
Apweiler R Exp Mol Med, 2018
NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction.
Gaude E Mol Cell, 2018