Saez-Rodriguez Group

Systems Biomedicine

Ece Kartal

I first enrolled in the Biology Department of Hacettepe University, followed by joining the Masters program in the Molecular Biology and Genetics Department of Bogazici University. The aim was to identify novel genes/mutations in neurodegenerative disorders using whole genome and exome sequencing methods.

In 2020, I finished my PhD in Computational Biology at EMBL, Heidelberg, which was followed by a short postdoctoral position. During my time at EMBL, I gained a lot of experience in both experimental and computational methods. For example, I developed a microbiome-based kit for colorectal cancer screening. I also analysed shotgun metagenomics and 16S rRNA sequencing data of different human microbiomes including gut, saliva and tissue. Computationally, I established different machine learning models for early detection of different diseases such as colon and pancreas cancers. In 2021, I joined the Saez-Rodriguez Lab at Heidelberg University Institute of Computational Biomedicine. I am currently working on unraveling the complex interactions between the host and microbiome at different levels in order to understand the underlying mechanisms of these interactions and translate this knowledge to the diagnostic and/ or therapeutic field.

Research Interests

I have a strong interest in medical and environmental microbiome research. I aim to integrate microbial information with other omics layers to have a broader understanding of complex disease mechanisms such as  cancer, heart failure and skin diseases.  My goal is to maximise usage of microbiome data and build multidimensional models. I am keen to unravel the complex interactions between the host and microbiome at different levels. I would like to understand the underlying mechanisms and translate this knowledge to the diagnostic and/ or therapeutic field by using the multi-omics data analysis approaches. Currently, I focus on host and microbiome interactions in lung cancer (PROMISE Consortium), heart failure and skin diseases (such as psoriasis, atopic dermatitis and rheumatoid arthritis).

Professional Career

2021-present Postdoctoral researcher – Institute for Computational Biomedicine, Heidelberg University, Germany
2020-2021 Postdoctoral researcher – European Molecular Biology Laboratory (EMBL), Heidelberg
2015-2015 Visiting Scientist – European Molecular Biology Laboratory (EMBL), Heidelberg

Education

2016-2020 PhD in Computational Biology – European Molecular Biology Laboratory (EMBL), Heidelberg
2012-2015 Masters of Science in Molecular Biology and Genetics – Bogazici University, Turkey
2007-2011 Bachelor of Science in Biology – Hacettepe University, Turkey