Saez-Rodriguez Group

Systems Biomedicine

Nadine Tüchler

After completing my Master degree in Medical and Pharmaceutical Biotechnology, I started my PhD in the groups of Rainer Pepperkok, Christoph Merten and Julio Saez-Rodriguez as a part of the Molecular Medicine Partnership Unit (MMPU). I plan to develop a new method for studying the underlying mechanisms and signaling networks that are dysregulated in Chronic Kidney Disease. For more information please click here

In my master thesis project at the lab of Giulio Superti-Furga, at CeMM Vienna, I studied the proteostasis of solute carries. For this purpose, I generated endogenously tagged cell lines and performed genetic as well as pharmacologic screens with focused libraries for the endoplasmic reticulum associated degradation and ubiquitin protein system.

I did my bachelor thesis internship in the lab of Manolis Fanto, at King’s College London. There, I investigated the role of three membrane proteins that are involved in the neuron-glia cross-talk in a Drosophila melanogaster model of Dentatorubral-pallidoluyisan atrophy (DRPLA), a rare neurodegenerative disease.

Research Interests

Driven by my aim to understand the complexity and underlying mechanisms of human diseases, I am focusing on kidney fibrosis in my PhD. By developing new approaches and advancing my imaging as well as image analysis skills, I plan to find dysregulated signaling networks within and between different cell types considering patient specific variances.

Professional Career

2019–present: PhD fellow at the groups of Rainer Pepperkok (EMBL Heidelberg), Christoph Merten (EPFL Lausanne) and Julio Saez-Rodriguez (Bioquant Heidelberg); Molecular Medicine Partnership Unit Heidelberg, Germany.
2018–2019: Diploma Student and Guest Scientist at Giulio Superti-Furga’s group, Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM) Vienna, Austria.
2017-2017: Research Intern at the Medical University Vienna, Austria.
2016-2016: Research Intern at the Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria.
2015–2016: Erasmus/Bachelor thesis internship at lab of Manolis Fanto, King’s College London, United Kingdom.


2016 – 2019: M.Sc. in Medical and Pharmaceutical Biotechnology, focus on Advanced Therapeutics Development. IMC University of Applied Sciences Krems, Austria.
2013 – 2016: B.Sc. in Medical and Pharmaceutical Biotechnology. IMC University of Applied Sciences Krems, Austria.