Saez-Rodriguez Group

Systems Biomedicine

Sophia Müller-Dott

I studied biochemistry at the Goethe University Frankfurt and then transitioned for my M.Sc. degree to the Heidelberg University, where I focused on computational biology. During my master’s thesis in Judith Zaugg’s group I was working on the reconstruction and comparison of gene regulatory networks across different immune cells, in particular CD4-positive T cells. In 2021, I joined the group of Julio Saez-Rodriguez as a PhD student. As part of the Liver Systems Medicine (LiSyM)-Cancer project, I will focus on the dissection of the tipping point from liver cirrhosis to hepatocellular carcinoma through multi-omics data analysis.

Research Interests

My main research interest is the combination of computational methods with biomedical knowledge to better understand regulatory mechanisms underlying human diseases, especially in the context of cancer and autoimmune diseases. I am interested in using multi-omics data integration to incorporate multiple layers of biological information and develop accurate biological models. These models allow the identification of structures and patterns underpinning pathological processes.

Professional Career

2021–present PhD Candidate, Institute for Computational Biomedicine, Heidelberg University, Faculty of Medicine & Heidelberg University Hospital, Germany
2020–2021 Master’s Thesis at EMBL Heidelberg, Zaugg Group, Germany
2020 Research internship at the Baker and Bio21 Institutes Melbourne, Ascher group, Australia
2019 Research internship at BASF SE in the Department of Experimental Toxicology and Ecology, Germany


2018–2021 M.Sc. Biochemistry, Heidelberg University, Germany
2015–2018 B.Sc. Biochemistry, Frankfurt University, Germany