Saez-Rodriguez Group

Hepatocytes reprogram liver macrophages involving control of TGF-β activation, influencing liver regeneration and injury.

Wolf et al. Hepatol Commun, 2023

A network medicine approach to study comorbidities in heart failure with preserved ejection fraction.

Lanzer et al. Bmc Med, 2023

Gene regulatory network inference in the era of single-cell multi-omics.

Badia-I-Mompel et al. Nat Rev Genet, 2023

Democratizing knowledge representation with BioCypher.

Lobentanzer et al. Nat Biotechnol, 2023

Proteomic Dynamics of Breast Cancer Cell Lines Identifies Potential Therapeutic Protein Targets.

Sun et al. Mol Cell Proteomics, 2023

Single-cell biology: what does the future hold?

Polychronidou et al. Mol Syst Biol, 2023

Best practices for single-cell analysis across modalities.

Heumos et al. Nat Rev Genet, 2023

International Society of Nephrology first consensus guidance for preclinical animal studies in translational nephrology.

Nangaku et al. Kidney Int, 2023

A T follicular helper cell origin for T regulatory type 1 cells.

Solé et al. Cell Mol Immunol, 2023

Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities.

Salovska et al. Clin Transl Med, 2023

Pan-Cancer landscape of protein activities identifies drivers of signalling dysregulation and patient survival.

Sousa et al. Mol Syst Biol, 2023

Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression.

Sciacovelli, Dugourd, et al. Nat Commun, 2022

Pre-analytical processing of plasma and serum samples for combined proteome and metabolome analysis.

Gegner et al. Front Mol Biosci, 2022

Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling.

Schreibing et al. Front Immunol, 2022

B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing.

Frede et al. Immunity, 2022

Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease.

Xu et al. Nat Genet, 2022

A microfluidic Braille valve platform for on-demand production, combinatorial screening and sorting of chemically distinct droplets.

Utharala et al. Nat Protoc, 2022

Cross-regional homeostatic and reactive glial signatures in multiple sclerosis.

Trobisch et al. Acta Neuropathol, 2022

Spatial multi-omic map of human myocardial infarction.

Kuppe, Ramirez Flores, Li, et al. Nature, 2022

decoupleR: Ensemble of computational methods to infer biological activities from omics data

Badia-i-Mompel et al. Bioinformatics Advances, 2022

Combi-seq for multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell droplets.

Mathur, Szalai, et al. Nat Commun, 2022

Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance.

Emdal et al. Cell Rep, 2022

Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment.

Schneider et al. Nat Commun, 2022

Integrating knowledge and omics to decipher mechanisms via large-scale models of signaling networks.

Garrido-Rodriguez et al. Mol Syst Biol, 2022

Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix.

Kay et al. Nat Metab, 2022