Saez-Rodriguez Group

Systems Biomedicine

Prediction of combination therapies based on topological modeling of the immune signaling network in multiple sclerosis

Bernardo-Faura et al. Genome Medicine, 2021

Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions.

Schwabenland et al. Immunity, 2021

Advances in systems biology modeling: 10 years of crowdsourcing DREAM challenges.

Meyer et al. Cell Syst, 2021

Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury.

Wijaya et al. Biochem Pharmacol, 2021

Deficiency of myeloid phd proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signaling

van Kuijk, Demandt, Perales-Patón et al. Cardiovascular Research, 2021

How will artificial intelligence and bioinformatics change our understanding of IgA Nephropathy in the next decade?

Büllow, Dimitrov, et al. et al. Seminars in Immunopathology, 2021

Consensus Transcriptional Landscape of Human End‐Stage Heart Failure

Ramirez-Flores, Lanzer et al. JAHA, 2021

Integrated intra- and intercellular signaling knowledge for multicellular omics analysis.

Türei et al. Mol Syst Biol, 2021

Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation.

Petkevicius et al. Faseb J, 2021

Differential expression of microRNA miR-150-5p in IgA nephropathy as a potential mediator and marker of disease progression.

Pawluczyk et al. Kidney Int, 2021

Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses.

Dugourd et al. Mol Syst Biol, 2021

Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ.

Cappelletti et al. Cell, 2020

Experimental and computational technologies to dissect the kidney at the single-cell level.

Kuppe et al. Nephrol Dial Transplant, 2020

Why do pathway methods work better than they should?

Szalai et al. Febs Lett, 2020

A statistical framework for assessing pharmacological responses and biomarkers using uncertainty estimates.

Wang et al. Elife, 2020

Decoding myofibroblast origins in human kidney fibrosis.

Kuppe et al. Cah Rev The, 2020

Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis.

Mohs et al. J Hepatol, 2020

Only Hyperuricemia with Crystalluria, but not Asymptomatic Hyperuricemia, Drives Progression of Chronic Kidney Disease.

Sellmayr et al. J Am Soc Nephrol, 2020

BIAS: Transparent reporting of biomedical image analysis challenges

Maier-Hein et al. Med Image Anal, 2020

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

Bouhaddou et al. Cell, 2020

Community Assessment of the Predictability of Cancer Protein and Phosphoprotein Levels from Genomics and Transcriptomics.

Yang et al. Cell Syst, 2020

CELLector: Genomics-Guided Selection of Cancer In Vitro Models.

Najgebauer et al. Cell Syst, 2020

Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data.

Holland et al. Genome Biol, 2020

Patient-specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies.

Eduati et al. Mol Syst Biol, 2020

Dysregulated mesenchymal PDGFR-β drives kidney fibrosis.

Buhl et al. Embo Mol Med, 2020