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Bernardo-Faura et al. Genome Medicine, 2021
Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions.
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Advances in systems biology modeling: 10 years of crowdsourcing DREAM challenges.
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Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury.
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Deficiency of myeloid phd proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signaling
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How will artificial intelligence and bioinformatics change our understanding of IgA Nephropathy in the next decade?
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Consensus Transcriptional Landscape of Human End‐Stage Heart Failure
Ramirez-Flores, Lanzer et al. JAHA, 2021
Integrated intra- and intercellular signaling knowledge for multicellular omics analysis.
Türei et al. Mol Syst Biol, 2021
Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation.
Petkevicius et al. Faseb J, 2021
Differential expression of microRNA miR-150-5p in IgA nephropathy as a potential mediator and marker of disease progression.
Pawluczyk et al. Kidney Int, 2021
Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses.
Dugourd et al. Mol Syst Biol, 2021
Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ.
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Experimental and computational technologies to dissect the kidney at the single-cell level.
Kuppe et al. Nephrol Dial Transplant, 2020
Why do pathway methods work better than they should?
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A statistical framework for assessing pharmacological responses and biomarkers using uncertainty estimates.
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Decoding myofibroblast origins in human kidney fibrosis.
Kuppe et al. Cah Rev The, 2020
Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis.
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Only Hyperuricemia with Crystalluria, but not Asymptomatic Hyperuricemia, Drives Progression of Chronic Kidney Disease.
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BIAS: Transparent reporting of biomedical image analysis challenges
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The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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Community Assessment of the Predictability of Cancer Protein and Phosphoprotein Levels from Genomics and Transcriptomics.
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CELLector: Genomics-Guided Selection of Cancer In Vitro Models.
Najgebauer et al. Cell Syst, 2020
Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data.
Holland et al. Genome Biol, 2020
Patient-specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies.
Eduati et al. Mol Syst Biol, 2020
Dysregulated mesenchymal PDGFR-β drives kidney fibrosis.
Buhl et al. Embo Mol Med, 2020