New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids.
Rodrigues et al. Arch Toxicol, 2021
Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions.
Schwabenland et al. Immunity, 2021
Advances in systems biology modeling: 10 years of crowdsourcing DREAM challenges.
Meyer et al. Cell Syst, 2021
Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury.
Wijaya et al. Biochem Pharmacol, 2021
Deciphering the signaling network of breast cancer improves drug sensitivity prediction.
Tognetti et al. Cell Syst, 2021
Transcription Factor Activity Inference in Systemic Lupus Erythematosus.
Lopez-Dominguez et al. Life (Basel), 2021
The Minimum Information about a Molecular Interaction CAusal STatement (MI2CAST).
Touré et al. Bioinformatics, 2021
Consensus Transcriptional Landscape of Human End-Stage Heart Failure.
Ramirez et al. J Am Heart Assoc, 2021
Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function.
Petkevicius et al. Mol Metab, 2021
PHONEMeS: Efficient Modeling of Signaling Networks Derived from Large-Scale Mass Spectrometry Data.
Gjerga et al. J Proteome Res, 2021
Integrated intra- and intercellular signaling knowledge for multicellular omics analysis.
Türei et al. Mol Syst Biol, 2021
Statistical and Machine Learning Techniques in Human Microbiome Studies: Contemporary Challenges and Solutions.
Moreno-Indias et al. Front Microbiol, 2021
Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation.
Petkevicius et al. Faseb J, 2021
Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses.
Dugourd et al. Mol Syst Biol, 2021
A statistical framework for assessing pharmacological responses and biomarkers using uncertainty estimates.
Wang et al. Elife, 2020
Decoding myofibroblast origins in human kidney fibrosis.
Kuppe et al. Nature, 2020
Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis.
Mohs et al. J Hepatol, 2020
The tissue proteome in the multi-omic landscape of kidney disease.
Rinschen et al. Nat Rev Nephrol, 2020
Big Data Approaches in Heart Failure Research.
Lanzer et al. Curr Heart Fail Rep, 2020
Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN.
Gleitz et al. Blood, 2020
Gene selection for optimal prediction of cell position in tissues from single-cell transcriptomics data.
Tanevski et al. Life Sci Alliance, 2020
Only Hyperuricemia with Crystalluria, but not Asymptomatic Hyperuricemia, Drives Progression of Chronic Kidney Disease.
Sellmayr et al. J Am Soc Nephrol, 2020
Inferring clonal composition from multiple tumor biopsies.
Manica et al. NPJ Syst Biol Appl, 2020
BIAS: Transparent reporting of biomedical image analysis challenges
Maier-Hein et al. Med Image Anal, 2020
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Bouhaddou et al. Cell, 2020