NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction.
Gaude E Mol Cell, 2018
Perturbation-response genes reveal signaling footprints in cancer gene expression.
Schubert M Nat Commun, 2018
A systematic atlas of chaperome deregulation topologies across the human cancer landscape.
Hadizadeh Esfahani A PLoS Comput Biol, 2018
Phosphoproteomics-Based Profiling of Kinase Activities in Cancer Cells.
Wirbel J Methods Mol Biol, 2018
Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer.
Garcia-Alonso L Cancer Res, 2017
Systems Pharmacology Dissection of Cholesterol Regulation Reveals Determinants of Large Pharmacodynamic Variability between Cell Lines.
Blattmann P Cell Syst, 2017
Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting
Iorio F , 2017
Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells.
Gonçalves E Metab Eng, 2017
Widespread Post-transcriptional Attenuation of Genomic Copy-Number Variation in Cancer.
Gonçalves E Cell Syst, 2017
A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines.
Gönen M Cell Syst, 2017
A parallel metaheuristic for large mixed-integer dynamic optimization problems, with applications in computational biology.
Penas DR PLoS One, 2017
Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells.
Roumeliotis TI Cell Rep, 2017
Logic Modeling in Quantitative Systems Pharmacology.
Traynard P CPT Pharmacometrics Syst Pharmacol, 2017
GDSCTools for Mining Pharmacogenomic Interactions in Cancer
Cokelaer T , 2017
Benchmarking substrate-based kinase activity inference using phosphoproteomic data.
Hernandez-Armenta C Bioinformatics, 2017
A Systematic Atlas of Chaperome Deregulation Topologies Across the Human Cancer Landscape
Hadizadeh Esfahani A , 2017
Mechanism-based biomarker discovery.
Antoranz A Drug Discov Today, 2017
Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.
Schneider RK Cell Stem Cell, 2017
Transcription factor activities enhance markers of drug response in cancer
Garcia-Alonso L , 2017
caspo: a toolbox for automated reasoning on the response of logical signaling networks families.
Videla S Bioinformatics, 2017
Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.
Brammeld JS Genome Res, 2017
Data-driven reverse engineering of signaling pathways using ensembles of dynamic models.
Henriques D PLoS Comput Biol, 2017
Systematic Analysis of Transcriptional and Post-transcriptional Regulation of Metabolism in Yeast.
Gonçalves E PLoS Comput Biol, 2017
System-Wide Quantitative Proteomics of the Metabolic Syndrome in Mice: Genotypic and Dietary Effects.
Terfve C J Proteome Res, 2017
Efficient randomization of biological networks while preserving functional characterization of individual nodes.
Iorio F BMC Bioinformatics, 2016