GDSCTools for mining pharmacogenomic interactions in cancer.
Cokelaer et al. Bioinformatics, 2018
Whither systems medicine?
Apweiler et al. Exp Mol Med, 2018
NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction.
Gaude et al. Mol Cell, 2018
Perturbation-response genes reveal signaling footprints in cancer gene expression.
Schubert et al. Nat Commun, 2018
A systematic atlas of chaperome deregulation topologies across the human cancer landscape.
Hadizadeh et al. Plos Comput Biol, 2018
Phosphoproteomics-Based Profiling of Kinase Activities in Cancer Cells.
Wirbel et al. Methods Mol Biol, 2018
Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer.
Garcia-Alonso et al. Cancer Res, 2017
Systems Pharmacology Dissection of Cholesterol Regulation Reveals Determinants of Large Pharmacodynamic Variability between Cell Lines.
Blattmann et al. Cell Syst, 2017
Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells.
Gonçalves et al. Metab Eng, 2017
Widespread Post-transcriptional Attenuation of Genomic Copy-Number Variation in Cancer.
Gonçalves et al. Cell Syst, 2017
A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines.
Gönen et al. Cell Syst, 2017
A parallel metaheuristic for large mixed-integer dynamic optimization problems, with applications in computational biology.
Penas et al. Plos One, 2017
Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells.
Roumeliotis et al. Cell Rep, 2017
Logic Modeling in Quantitative Systems Pharmacology.
Traynard et al. CPT Pharmacometrics Syst Pharmacol, 2017
Benchmarking substrate-based kinase activity inference using phosphoproteomic data.
Hernandez-Armenta et al. Bioinformatics, 2017
Mechanism-based biomarker discovery.
Antoranz et al. Drug Discov Today, 2017
Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.
Schneider et al. Cell Stem Cell, 2017
Drug Resistance Mechanisms in Colorectal Cancer Dissected with Cell Type-Specific Dynamic Logic Models.
Eduati et al. Cancer Res, 2017
caspo: a toolbox for automated reasoning on the response of logical signaling networks families.
Videla et al. Bioinformatics, 2017
Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.
Brammeld et al. Genome Res, 2017
Data-driven reverse engineering of signaling pathways using ensembles of dynamic models.
Henriques et al. Plos Comput Biol, 2017
Systematic Analysis of Transcriptional and Post-transcriptional Regulation of Metabolism in Yeast.
Gonçalves et al. Plos Comput Biol, 2017
System-Wide Quantitative Proteomics of the Metabolic Syndrome in Mice: Genotypic and Dietary Effects.
Terfve et al. J Proteome Res, 2017
Efficient randomization of biological networks while preserving functional characterization of individual nodes.
Iorio et al. Bmc Bioinformatics, 2016
Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.
Mateo et al. Oncogene, 2016