Saez-Rodriguez Group

Systems Biomedicine

A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury.

Wijaya et al. Toxicol Sci, 2024

Profiling the heterogeneity of colorectal cancer consensus molecular subtypes using spatial transcriptomics.

Valdeolivas et al. NPJ Precis Oncol, 2024

Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage.

Ghasemi et al. Nat Commun, 2024

Metabolic Communication by SGLT2 Inhibition.

Billing et al. Circulation, 2023

Predicting disease severity in multiple sclerosis using multimodal data and machine learning.

Andorra et al. J Neurol, 2023

Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics.

Engblom et al. Science, 2023

Mapping cardiac remodeling in chronic kidney disease.

Kaesler et al. Sci Adv, 2023

Multicellular factor analysis of single-cell data for a tissue-centric understanding of disease.

Ramirez et al. Elife, 2023

Expanding the coverage of regulons from high-confidence prior knowledge for accurate estimation of transcription factor activities.

Müller-Dott et al. Nucleic Acids Res, 2023

A machine learning and directed network optimization approach to uncover TP53 regulatory patterns.

Triantafyllidis et al. iScience, 2023

Enablers and challenges of spatial omics, a melting pot of technologies.

Alexandrov et al. Mol Syst Biol, 2023

Democratizing knowledge representation with BioCypher.

Lobentanzer et al. Nat Biotechnol, 2023

Hepatocytes reprogram liver macrophages involving control of TGF-β activation, influencing liver regeneration and injury.

Wolf et al. Hepatol Commun, 2023

A network medicine approach to study comorbidities in heart failure with preserved ejection fraction.

Lanzer et al. Bmc Med, 2023

Gene regulatory network inference in the era of single-cell multi-omics.

Badia-I-Mompel et al. Nat Rev Genet, 2023

Democratizing knowledge representation with BioCypher.

Lobentanzer et al. Nat Biotechnol, 2023

Proteomic Dynamics of Breast Cancer Cell Lines Identifies Potential Therapeutic Protein Targets.

Sun et al. Mol Cell Proteomics, 2023

Single-cell biology: what does the future hold?

Polychronidou et al. Mol Syst Biol, 2023

Best practices for single-cell analysis across modalities.

Heumos et al. Nat Rev Genet, 2023

International Society of Nephrology first consensus guidance for preclinical animal studies in translational nephrology.

Nangaku et al. Kidney Int, 2023

A T follicular helper cell origin for T regulatory type 1 cells.

Solé et al. Cell Mol Immunol, 2023

Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities.

Salovska et al. Clin Transl Med, 2023

Pan-Cancer landscape of protein activities identifies drivers of signalling dysregulation and patient survival.

Sousa et al. Mol Syst Biol, 2023

Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression.

Sciacovelli, Dugourd, et al. Nat Commun, 2022

Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease.

Xu et al. Nat Genet, 2022