Saez-Rodriguez Group

Systems Biomedicine

Deciphering the signaling network of breast cancer improves drug sensitivity prediction.

Tognetti et al. Cell Syst, 2021

Transcription Factor Activity Inference in Systemic Lupus Erythematosus.

Lopez-Dominguez et al. Life (Basel), 2021

The Minimum Information about a Molecular Interaction CAusal STatement (MI2CAST).

Touré et al. Bioinformatics, 2021

Consensus Transcriptional Landscape of Human End-Stage Heart Failure.

Ramirez et al. J Am Heart Assoc, 2021

Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function.

Petkevicius et al. Mol Metab, 2021

PHONEMeS: Efficient Modeling of Signaling Networks Derived from Large-Scale Mass Spectrometry Data.

Gjerga et al. J Proteome Res, 2021

Integrated intra- and intercellular signaling knowledge for multicellular omics analysis.

Türei et al. Mol Syst Biol, 2021

Statistical and Machine Learning Techniques in Human Microbiome Studies: Contemporary Challenges and Solutions.

Moreno-Indias et al. Front Microbiol, 2021

Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation.

Petkevicius et al. Faseb J, 2021

Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses.

Dugourd et al. Mol Syst Biol, 2021

A statistical framework for assessing pharmacological responses and biomarkers using uncertainty estimates.

Wang et al. Elife, 2020

Decoding myofibroblast origins in human kidney fibrosis.

Kuppe et al. Nature, 2020

Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis.

Mohs et al. J Hepatol, 2020

The tissue proteome in the multi-omic landscape of kidney disease.

Rinschen et al. Nat Rev Nephrol, 2020

Big Data Approaches in Heart Failure Research.

Lanzer et al. Curr Heart Fail Rep, 2020

Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN.

Gleitz et al. Blood, 2020

Gene selection for optimal prediction of cell position in tissues from single-cell transcriptomics data.

Tanevski et al. Life Sci Alliance, 2020

Only Hyperuricemia with Crystalluria, but not Asymptomatic Hyperuricemia, Drives Progression of Chronic Kidney Disease.

Sellmayr et al. J Am Soc Nephrol, 2020

Inferring clonal composition from multiple tumor biopsies.

Manica et al. NPJ Syst Biol Appl, 2020

BIAS: Transparent reporting of biomedical image analysis challenges

Maier-Hein et al. Med Image Anal, 2020

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

Bouhaddou et al. Cell, 2020

SBML Level 3: an extensible format for the exchange and reuse of biological models.

Keating et al. Mol Syst Biol, 2020

Converting networks to predictive logic models from perturbation signalling data with CellNOpt.

Gjerga et al. Bioinformatics, 2020

Community Assessment of the Predictability of Cancer Protein and Phosphoprotein Levels from Genomics and Transcriptomics.

Yang et al. Cell Syst, 2020

Stratification and prediction of drug synergy based on target functional similarity.

Yang et al. NPJ Syst Biol Appl, 2020